SCIENTIFIC PUBLICATIONS

Original Research

Talbot NP, Cheng H, Hanstock H, Smith TG, Dorrington KL and Robbins PA. Hypoxic pulmonary vasoconstriction does not limit maximal exercise capacity in healthy volunteers breathing 12% oxygen at sea level. Physiological Reports 2024;12(4): e15944.   [pubmed]  [online]  [pdf]

Brown LA, Griffiths JA, Santer P, Jakeman PM and Smith TG. Potential for using simulated altitude as a means of prehabilitation: a physiology study. Anaesthesia 2023; 78(12): 1472-1480.   [pubmed]  [online]  [pdf]

Connolly DM, Madden LA, Edwards VC, D’Oyly TJ, Harridge SD, Smith TG and Lee VM. Early human pathophysiological response to exertional hypobaric decompression stress. Aerospace Medicine and Human Performance 2023; 94(10): 738-749.   [pubmed]  [online]  [pdf]

Connolly DM, D’Oyly TJ, Harridge SDR, Smith TG and Lee VM. Decompression sickness risk in parachutist despatchers exposed repeatedly to high altitude. Aerospace Medicine and Human Performance 2023; 94(9): 666-677.   [pubmed]  [online]  [pdf]

Haddon A, Kanhai J, Nako O, Smith TG, Hodkinson PD and Pollock RD. Cardiorespiratory responses to voluntary hyperventilation during normobaric hypoxia. Aerospace Medicine and Human Performance 2023; 94(2): 59-65.   [pubmed]  [online]  [pdf]

Hearn E, Byford J, Wolfe C, Agyei C, Hodkinson PD, Pollock RD and Smith TG. Measuring arterial oxygen saturation using wearable devices under varying conditions. Aerospace Medicine and Human Performance 2023; 94(1): 42-47.   [pubmed]  [online]  [pdf]

Smith TG, Pollock RD, Britton JK, Green NDC, Hodkinson PD, Mitchell SJ, Stevenson AT. Physiological effects of centrifuge-simulated suborbital spaceflight. Aerospace Medicine and Human Performance 2022; 93(12): 830-839.   [pubmed]  [online]  [pdf]

Smith TG, Anastasescu I, Wight JM, Danaee A, Nair R and O'Brien TS. Perioperative management including dual cell salvage in a Jehovah’s Witness patient undergoing major urological surgery. Clinical Case Reports 2021; 9(11): e05098.   [pubmed]  [online]  [pdf]

Menden T, Alcaín GB, Stevenson AT, Pollock RD, Tank H, Hodkinson PD, Jolley CJ, Smith TG, Leonhardt S and Walter M. Dynamic lung behavior under high G acceleration monitored with electrical impedance tomography. Physiological Measurement 2021; 42: 094001   [pubmed]  [online]  [pdf]

Pollock RD, Jolley CJ, Abid N, Couper JH, Estrada-Petrocelli L, Hodkinson PD, Leonhardt S, Magor-Elliott S, Menden T, Rafferty G, Richmond G, Robbins PA, Ritchie GAD, Segal MJ, Stevenson AT, Tank HD and Smith TG. Pulmonary effects of sustained periods of high-G acceleration relevant to suborbital spaceflight. Aerospace Medicine and Human Performance 2021; 92(8): 633-641.   [pubmed]  [online]  [pdf]

Smith TG, Ahmad I, Takhar A, Surda P and El-Boghdadly K. Unconventional multidisciplinary team strategy for tracheostomy in COVID-19. Anaesthesia Reports 2020; 8: 176-179.   [pubmed]  [online]  [pdf]

Talbot NP, Smith TG, Balanos GM, Dorrington KL, Maxwell PH and Robbins PA. Cardiopulmonary phenotype associated with human PHD2 mutation. Physiological Reports 2017; 5(7): e13224.   [pubmed]  [online]  [pdf]

Smith TG, Formenti F, Hodkinson PD, Khpal M, Mackenwells BP and Talbot NP. Monitoring tissue oxygen saturation in microgravity on parabolic flights. Gravitational and Space Research 2016; 4(2): 2-7.   [online]  [pdf]

Talbot NP, Smith TG, Lakhal-Littleton S, Gülsever C, Rivera-Ch M, Dorrington KL, Mole DR and Robbins PA. Suppression of plasma hepcidin by venesection during steady-state hypoxia. Blood 2016; 127(9): 1206-1207.   [pubmed]  [online]  [pdf]

Fatemian M, Herigstad M, Croft QP, Formenti F, Cardenas R, Wheeler C, Smith TG, Friedmannova M, Dorrington KL and Robbins PA. Determinants of ventilation and pulmonary artery pressure during early acclimatization to hypoxia in humans. Journal of Physiology 2016; 594(5): 1197-1213.   [pubmed]  [online]  [pdf]

Turner BE, Hodkinson PD, Timperley AC and Smith TG. Pulmonary artery pressure response to simulated air travel in a hypobaric chamber. Aerospace Medicine and Human Performance 2015; 86(6): 529-534.   [pubmed]  [online]  [pdf]

Talbot NP, Croft QP, Curtis MK, Turner BE, Dorrington KL, Robbins PA and Smith TG. Contrasting effects of ascorbate and iron on the pulmonary vascular response to hypoxia in humans. Physiological Reports 2014; 2(12): e12220.   [pubmed]  [online]  [pdf]

Bishop T, Talbot NP, Turner PJ, Nicholls LG, Pascual A, Hodson EJ, Douglas G, Fielding JW, Smith TG, Demetriades M, Schofield CJ, Robbins PA, Pugh CW, Buckler KJ and Ratcliffe PJ. Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2. Journal of Physiology 2013; 591(14): 3565-3577.   [pubmed]  [online]  [pdf]

Liu C, Croft QP, Kalidhar S, Brooks JT, Herigstad M, Smith TG, Dorrington KL and Robbins PA. Dexamethasone mimics aspects of physiological acclimatization to eight hours of hypoxia but suppresses plasma erythropoietin. Journal of Applied Physiology 2013; 114(7): 948-956.   [pubmed]  [online]  [pdf]

Smith TG, Chang RW, Robbins PA and Dorrington KL. Commercial air travel and in-flight pulmonary hypertension. Aviation, Space and Environmental Medicine 2013; 84(1): 65-67.  [pubmed]  [online]  [pdf]

Smith TG, Talbot NP, Chang RW, Wilkinson E, Nickol AH, Newman DG, Robbins PA and Dorrington KL. Pulmonary artery pressure increases during commercial air travel in healthy passengers. Aviation, Space and Environmental Medicine 2012; 83(7): 673-676.  [pubmed]  [online]  [pdf]

Talbot NP, Lakhal S, Smith TG, Privat C, Nickol AH, Rivera-Ch M, León-Velarde F, Dorrington KL, Mole DR and Robbins PA. Regulation of hepcidin expression at high altitude. Blood 2012; 119(3): 857-860.  [pubmed]  [online]  [pdf]

Talbot NP, Smith TG, Privat C, Nickol AH, Rivera-Ch, M, León-Velarde F, Dorrington KL and Robbins PA. Intravenous iron supplementation may protect against acute mountain sickness: a randomized, double-blinded, placebo-controlled trial. High Altitude Medicine and Biology 2011; 12(3): 265-269.  [pubmed]  [online]  [pdf]

Formenti F, Beer PA, Croft QP, Dorrington KL, Gale DP, Lappin TR, Lucas GS, Maher ER, Maxwell PH, McMullin MF, O'Connor DF, Percy MJ, Pugh CW, Ratcliffe PJ, Smith TG, Talbot NP and Robbins PA. Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation. FASEB Journal 2011; 25(6): 2001-2011.  [pubmed]  [online]  [pdf]

Formenti F, Constantin-Teodosiu D, Emmanuel Y, Cheeseman J, Dorrington KL, Edwards LM, Humphreys SM, Lappin TR, McMullin MF, McNamara CJ, Mills W, Murphy JA, O'Connor DF, Percy MJ, Ratcliffe PJ, Smith TG, Treacy M, Frayn KN, Greenhaff PL, Karpe F, Clarke K and Robbins PA. Regulation of human metabolism by hypoxia-inducible factor. Proceedings of the National Academy of Sciences of the USA 2010; 107(28): 12722-12727.  [pubmed]  [online]  [pdf]

Smith TG, Talbot NP, Privat C, Rivera-Ch M, Nickol AH, Ratcliffe PJ, Dorrington KL, León-Velarde F and Robbins PA. Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials. Journal of the American Medical Association 2009; 302(13): 1444-1450.  [pubmed]  [online]  [pdf]

Brooks JT, Elvidge GP, Glenny L, Gleadle JM, Liu C, Ragoussis I, Smith TG, Talbot NP, Winchester L, Maxwell PH and Robbins PA. Variations within oxygen-regulated gene expression in humans. Journal of Applied Physiology 2009; 106(1): 212-220.  [pubmed]  [online]  [pdf]

Smith TG, Balanos GM, Croft QP, Talbot NP, Dorrington KL, Ratcliffe PJ and Robbins PA. The increase in pulmonary arterial pressure caused by hypoxia depends on iron status. Journal of Physiology 2008; 586(24): 5999-6005.  [pubmed]  [online]  [pdf]
     Related editorial:  'Iron lung? New ideas about hypoxic pulmonary vasoconstriction'  [pubmed]  [online]  [pdf]

Liu C, Balanos GM, Fatemian M, Smith TG, Dorrington KL and Robbins PA. Effects of hydralazine on the pulmonary vasculature and respiratory control in humans. Experimental Physiology 2008;  93(1): 104-114.  [pubmed]  [online]  [pdf]

Liu C, Smith TG, Balanos GM, Brooks JT, Crosby A, Herigstad M, Dorrington KL and Robbins PA. Lack of involvement of the autonomic nervous system in early ventilatory and pulmonary vascular acclimatization to hypoxia in humans. Journal of Physiology 2007; 579(1): 215-225.  [pubmed]  [online]  [pdf]

Smith TG, Brooks JT, Balanos GM, Lappin TR, Layton DM, Leedham DL, Liu C, Maxwell PH, McMullin MF, McNamara CJ, Percy MJ, Pugh CW, Ratcliffe PJ, Talbot NP, Treacy M and Robbins PA. Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS Medicine 2006; 3(7): 1178-1185.  [pubmed]  [online]  [pdf]

Reviews

Pollock RD, Hodkinson PD, and Smith TG. Oh G: The x, y and z of human physiological responses to acceleration. Experimental Physiology 2021; 106(12): 2367-2384.  [pubmed]  [online]  [pdf]

Talbot NP, Smith TG and Dorrington KL. The mechanics and control of ventilation. Surgery 2011; 29: 212-216.  [online]  [pdf]

Nagel S, Talbot NP, Mecinović J, Smith TG, Buchan AM and Schofield CJ. Therapeutic manipulation of the HIF hydroxylases. Antioxidants and Redox Signaling 2010; 12(4): 481-501.  [pubmed]  [online]  [pdf]

Smith TG, Robbins PA and Ratcliffe PJ. The human side of hypoxia-inducible factor. British Journal of Haematology 2008; 141: 325-334.  [pubmed]  [online]  [pdf]

Editorials

Smith TG and Buckey JC. Anaesthetists and aerospace medicine in a new era of human spaceflight. Anaesthesia 2022; 77(4): 384-388.  [pubmed]  [online]  [pdf]

Smith TG. Extraterrestrial autonomic function. Clinical Autonomic Research 2018; 28(3): 263-264.  [pubmed]  [online]  [pdf]

Smith TG and Talbot NP. Prolyl hydroxylases and therapeutics. Antioxidants and Redox Signaling 2010; 12(4): 431-433.  [pubmed]  [online]  [pdf]

 
Book Chapters

Smith TG. Cardiovascular physiology. In: Ernsting’s Aviation and Space Medicine. Eds: Gradwell D, Wilkinson E. CRC Press, London (6th edition): in press.

Smith TG, Brooks JT, Balanos GM, Lappin TR, Layton DM, Leedham DL, Liu C, Maxwell PH, McMullin MF, McNamara CJ, Percy MJ, Pugh CW, Ratcliffe PJ, Talbot NP, Treacy M and Robbins PA. Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology. In: Integration in Respiratory Control – from Genes to Systems (Advances in Experimental Medicine and Biology Series). Eds: Poulin MJ and Wilson RJA. Springer Publishers, New York, 2008.  [pdf]

Correspondence

Smith TG and Talbot NP. Aircraft cabin hypoxia and adverse medical events. JAMA 2019; 321(20): 2030.  [pubmed]  [online]  [pdf]

Talbot NP, Frise MC and Smith TG. Iron availability and outcomes in critical illness. Critical Care Medicine 2016; 44(10): e1011.  [pubmed]  [online]  [pdf]

Smith TG. How much hypoxia is significant in pulmonary hypertension during air travel? Chest 2013; 143(3):876-877.  [pubmed]  [online]  [pdf]

Smith TG, Talbot NP, Dorrington KL and Robbins PA. Intravenous iron and pulmonary hypertension in intensive care. Intensive Care Medicine 2011; 37(10): 1720.  [pubmed]  [online]  [pdf]

Smith TG. Erythropoietin and HAPE. Aviation, Space and Environmental Medicine 2008; 79(8): 807.  [pubmed]  [online]  [pdf]

Smith TG and Robbins PA. Iron, pre-eclampsia and hypoxia-inducible factor. BJOG 2007; 114: 1581-1582.  [pubmed]  [online]  [pdf]

Pattinson KT, Sutherland AI, Smith TG, Dorrington KL and Wright AD. Acute mountain sickness, vitamin C, free radicals and HIF-1α. Wilderness and Environmental Medicine 2005; 16: 172-173.  [pubmed]  [online]  [pdf]

Published Abstracts

Anderton RA, Pollock RD, Britton JK, Green NDC, Hendriksen D, Hodkinson PD and Smith TG. Prevention of visual symptoms during centrifuge-simulated suborbital spaceflight. Aerospace Medicine and Human Performance 2024 (in press)

Smith TG, Hearn E, Byford J, Wolfe C, Agyei C, Hodkinson PD and Pollock RD. Measuring arterial oxygen saturation using wearable devices under conditions relevant to the flight environment: a preliminary study. Aerospace Medicine and Human Performance 2023; 94(4): 235.  [pdf]

Pollock RD, Coonjobeeharry M, Bychkov I, Maanum L, Coffey A, Bilger C, Rafferty G, Jolley CJ, Hodkinson PD and Smith TG. Influence of seat back angle and flight jacket wear on work of breathing. Aerospace Medicine and Human Performance 2023; 94(4): 191-192.  [pdf]

Di Giulio I, Anderton RA, Harridge S, Hodkinson PD, Narici M, Pollock RD, Rittweger J, Smith TG and Miller-Smith M. Investigating the potential for parastronauts: support for the ESA parastronaut project. Aerospace Medicine and Human Performance 2023; 94(4): 309.  [pdf]

Lee VM, Connolly DM, D'Oyly TD and Smith TG. Decompression sickness risk associated with repeat altitude exposure. Aerospace Medicine and Human Performance 2023; 94(4): 161.  [pdf]

Smith TG, Pollock RD, Britton J, Green NDC, Hodkinson PD, Mitchell SJ and Stevenson AT. Physiological effects of centrifuge-simulated suborbital spaceflight. Aerospace Medicine and Human Performance 2022; 93(3): 155.  [pdf]

Britton J, Pollock RD, Green NDC, Hodkinson PD, Mitchell SJ, Stevenson AT and Smith TG. Visual symptoms and G-LOC during centrifuge-simulated suborbital spaceflight. Aerospace Medicine and Human Performance 2022; 93(3): 154.  [pdf]

Smith TG. Hypoxic pulmonary vasoconstriction during air travel. Aerospace Medicine and Human Performance 2020; 91(3): 220.  [pdf]

Stevenson AT, Pollock RD, Tank HD, Magor-Elliott S, Couper JH, Richmond G, Abid N, Hodkinson PD, Ritchie GA, Robbins PA and Smith TG. Impairment of gas exchange in the lung during sustained +Gx acceleration relevant to suborbital spaceflight profiles. Aerospace Medicine and Human Performance 2019; 90(3): 294.  [pdf]

Pollock RD, Stevenson AT, Jolley CJ, Rafferty GF, Estrada L, Segal MJ, Tank HD, Menden T, Leonhardt S and Smith TG. Ventilation, respiratory drive and breathing mechanics during sustained +Gx acceleration relevant to suborbital spaceflight profiles. Aerospace Medicine and Human Performance 2019; 90(3): 295.  [pdf]

Talbot NP, Cheng H, Smith TG, Dorrington KL and Robbins PA. Effects of intravenous iron on hypoxic pulmonary vasoconstriction and maximal exercise capacity during sustained (8 h) hypoxia in healthy volunteers. European Respiratory Journal 2018 52: Suppl. 62, PA2477.  [pdf]

Posselt B, Anderton RA, Komorowski M, Healy B, Smith TG, Whittle RS, Fong K and Hodkinson PD. Medical challenges and considerations for an established lunar base. Aerospace Medicine and Human Performance 2018; 89(3): 192.  [pdf]

Russomano T, Gradwell D, Smith TG and Harridge S. Aerospace physiology and medicine at King’s College London. Aerospace Medicine and Human Performance 2018; 89(3): 224-225.  [pdf]

Middleton KE and Smith TG. Existing provision for emergency medical services at candidate sites for a UK spaceport. Aerospace Medicine and Human Performance 2017; 88(3): 291.  [pdf]

Turner BE, Hodkinson PD, Timperley AC and Smith TG. Effect of age on the pulmonary artery pressure response to simulated air travel. Aerospace Medicine and Human Performance 2015; 86(3): 245.  [pdf]

Brown LA, Prasad P, Smith TG and Johnston B. Pulmonary hypertension in airline passengers: a large case series from Oceania. Aerospace Medicine and Human Performance 2015; 86(3): 245.  [pdf]

Brown LA, Ho H, Smith TG, Windsor J and Phillips A. Feasibility of surgical percutaneous drain use in the microgravity environment. Aerospace Medicine and Human Performance 2015; 86(3): 162.  [pdf]

Smith TG. Mild hypoxia beyond the aircraft cabin. Aviation, Space and Environmental Medicine 2014; 85(3): 230.  [pdf]

Smith TG. Aviation hypoxia, cognition and human performance. Aviation, Space and Environmental Medicine 2013; 84(4): 425.  [pdf]

Smith TG, Talbot NP, Chang RW, Wilkinson E, Nickol AH, Newman DG, Robbins PA and Dorrington KL. Commercial air travel causes an increase in pulmonary artery pressure that can be clinically significant. Aviation, Space and Environmental Medicine 2013; 84(4): 377-378.  [pdf]

Smith TG. Recent advances in human pulmonary vascular physiology. Respiratory Investigation 2012; 75: EMS61.  [pdf]

Talbot NP, Bishop T, Nicholls LG, Smith TG, Dorrington KL, Buckler KJ, Robbins PA, Pugh CW and Ratcliffe PJ. A role for prolyl hydroxylase domain (PHD) proteins in respiratory control. American Journal of Respiratory and Critical Care Medicine 2011; 183: A6371.  [pdf]

Smith TG. Iron is an important factor in pulmonary physiology. Journal of the Intensive Care Society 2011; 12 (1): 57-58.  [pdf]

Formenti F, Beer P, Croft QP, Dorrington KL, Gale DP, Lappin TR, Lucas G, Maxwell PH, McMullin MF, O'Connor DF, Percy MJ, Smith TG, Talbot NP and Robbins PA. A 'gain-of-function' mutation in the hypoxia-inducible 2α gene does not reduce exercise capacity in humans. Journal of Physiological Sciences 2009; 59(Suppl. 1): 357.  [pdf]

Formenti F, Clarke K, Dorrington KL, Edwards L, Emmanuel Y, Lappin TR, McMullin MF, McNamara CJ, Mills W, Murphy JA, O'Connor DF, Percy MJ, Smith TG, Treacy M and Robbins PA. A genetic disease in humans demonstrates the importance of hypoxia-inducible factor in skeletal muscle metabolism. FASEB Journal 2009; 23: 955.32.  [pdf]

Smith TG, Bishop T, Carmeliet P, Dorrington KL, Maxwell PH, Pugh CW, Ratcliffe PJ and Robbins PA. The acute hypoxic ventilatory response is augmented in PHD2-deficient mice. American Journal of Respiratory and Critical Care Medicine 2008; 177: A270.  [pdf]

Smith TG, Croft QP, Dorrington KL and Robbins PA. Intravenous iron loading inhibits the pulmonary vascular response to hypoxia in humans. FASEB Journal 2007; 21: A1438.  [pdf]

Liu C, Balanos GM, Smith TG, Dorrington KL and Robbins PA. The effect of hydralazine on cardiorespiratory responses to hypoxia may not involve activation of the HIF pathway. FASEB Journal 2006; 20: LB30.  [pdf]

Smith TG, Ludbrook GL and van Renen G. Anaesthesia: a postoperative review. Anaesthesia and Intensive Care 1998; 26: 689.  [pdf]