Dr Thomas G. Smith  MBBS DPhil FRCA FAsMA

Clinical Senior Lecturer, Centre of Human and Aerospace Physiological Sciences, King’s College London
Honorary Consultant Anaesthetist, Guy’s Hospital, Guy's and St Thomas' NHS Foundation Trust, London

  • Clinician-scientist specialising in cardiopulmonary/hypoxia physiology, aerospace physiology/medicine and anaesthetics
  • Previously based at the University of Oxford (2003-2017)
  • Graduated from medicine at the University of Adelaide, Australia
  • Former Rhodes Scholar and Churchill Fellow
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SCIENTIFIC PUBLICATIONS:


Original Research

Talbot NP, Smith TG, Balanos GM, Dorrington KL, Maxwell PH and Robbins PA. Cardiopulmonary phenotype associated with human PHD2 mutation. Physiological Reports 2017; 5(7): e13224.   [pubmed]  [online]  [pdf]

Smith TG, Formenti F, Hodkinson PD, Khpal M, Mackenwells BP, Talbot NP. Monitoring tissue oxygen saturation in microgravity on parabolic flights. Gravitational and Space Research 2016; 4(2): 2-7.   [online]  [pdf]

Talbot NP, Smith TG, Lakhal-Littleton S, Gülsever C, Rivera-Ch M, Dorrington KL, Mole DR and Robbins PA. Suppression of plasma hepcidin by venesection during steady-state hypoxia. Blood 2016; 127(9): 1206-1207.   [pubmed]  [online]  [pdf]

Fatemian M, Herigstad M, Croft QP, Formenti F, Cardenas R, Wheeler C, Smith TG, Friedmannova M, Dorrington KL and Robbins PA. Determinants of ventilation and pulmonary artery pressure during early acclimatization to hypoxia in humans. Journal of Physiology 2016; 594(5): 1197-1213.   [pubmed]  [online]  [pdf]

Turner BE, Hodkinson PD, Timperley AC and Smith TG. Pulmonary artery pressure response to simulated air travel in a hypobaric chamber. Aerospace Medicine and Human Performance 2015; 86(6): 529-534.   [pubmed]  [online]  [pdf]

Talbot NP, Croft QP, Curtis MK, Turner BE, Dorrington KL, Robbins PA and Smith TG. Contrasting effects of ascorbate and iron on the pulmonary vascular response to hypoxia in humans. Physiological Reports 2014; 2(12): e12220.   [pubmed]  [online]  [pdf]

Bishop T, Talbot NP, Turner PJ, Nicholls LG, Pascual A, Hodson EJ, Douglas G, Fielding JW, Smith TG, Demetriades M, Schofield CJ, Robbins PA, Pugh CW, Buckler KJ and Ratcliffe PJ. Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2. Journal of Physiology 2013; 591(14): 3565-3577.   [pubmed]  [online]  [pdf]

Liu C, Croft QP, Kalidhar S, Brooks JT, Herigstad M, Smith TG, Dorrington KL and Robbins PA. Dexamethasone mimics aspects of physiological acclimatization to eight hours of hypoxia but suppresses plasma erythropoietin. Journal of Applied Physiology 2013; 114(7): 948-956.   [pubmed]  [online]  [pdf]

Smith TG, Chang RW, Robbins PA and Dorrington KL. Commercial air travel and in-flight pulmonary hypertension. Aviation, Space and Environmental Medicine 2013; 84(1): 65-67.  [pubmed]  [online]  [pdf]

Smith TG, Talbot NP, Chang RW, Wilkinson E, Nickol AH, Newman DG, Robbins PA and Dorrington KL. Pulmonary artery pressure increases during commercial air travel in healthy passengers. Aviation, Space and Environmental Medicine 2012; 83(7): 673-676.  [pubmed]  [online]  [pdf]

Talbot NP, Lakhal S, Smith TG, Privat C, Nickol AH, Rivera-Ch M, León-Velarde F, Dorrington KL, Mole DR and Robbins PA. Regulation of hepcidin expression at high altitude. Blood 2012; 119(3): 857-860 [pubmed]  [online]  [pdf]

Talbot NP, Smith TG, Privat C, Nickol AH, Rivera-Ch, M, León-Velarde F, Dorrington KL and Robbins PA. Intravenous iron supplementation may protect against acute mountain sickness: a randomized, double-blinded, placebo-controlled trial. High Altitude Medicine and Biology 2011; 12(3): 265-269 [pubmed]  [online]  [pdf]

Formenti F, Beer PA, Croft QP, Dorrington KL, Gale DP, Lappin TR, Lucas GS, Maher ER, Maxwell PH, McMullin MF, O'Connor DF, Percy MJ, Pugh CW, Ratcliffe PJ, Smith TG, Talbot NP and Robbins PA. Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation. FASEB Journal 2011; 25(6): 2001-2011.  [pubmed]  [online]  [pdf]

Formenti F, Constantin-Teodosiu D, Emmanuel Y, Cheeseman J, Dorrington KL, Edwards LM, Humphreys SM, Lappin TR, McMullin MF, McNamara CJ, Mills W, Murphy JA, O'Connor DF, Percy MJ, Ratcliffe PJ, Smith TG, Treacy M, Frayn KN, Greenhaff PL, Karpe F, Clarke K and Robbins PA. Regulation of human metabolism by hypoxia-inducible factor. Proceedings of the National Academy of Sciences of the USA 2010; 107(28): 12722-12727.  [pubmed]  [online]  [pdf]

Smith TG, Talbot NP, Privat C, Rivera-Ch M, Nickol AH, Ratcliffe PJ, Dorrington KL, León-Velarde F and Robbins PA. Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials. Journal of the American Medical Association 2009; 302(13): 1444-1450 [pubmed]  [online]  [pdf]

Brooks JT, Elvidge GP, Glenny L, Gleadle JM, Liu C, Ragoussis I, Smith TG, Talbot NP, Winchester L, Maxwell PH and Robbins PA. Variations within oxygen-regulated gene expression in humans. Journal of Applied Physiology 2009106(1): 212-220.  [pubmed]  [online]  [pdf]

Smith TG, Balanos GM, Croft QP, Talbot NP, Dorrington KL, Ratcliffe PJ and Robbins PA. The increase in pulmonary arterial pressure caused by hypoxia depends on iron status. Journal of Physiology 2008; 586(24): 5999-6005.  [pubmed]  [online [pdf]
     Related editorial: 
'Iron lung? New ideas about hypoxic pulmonary vasoconstriction' [online [pdf]

Liu C, Balanos GM, Fatemian M, Smith TG, Dorrington KL and Robbins PA. Effects of hydralazine on the pulmonary vasculature and respiratory control in humans. Experimental Physiology 2008;  93(1): 104-114.  [pubmed]  [online]  [pdf]

Liu C, Smith TG, Balanos GM, Brooks JT, Crosby A, Herigstad M, Dorrington KL and Robbins PA. Lack of involvement of the autonomic nervous system in early ventilatory and pulmonary vascular acclimatization to hypoxia in humans. Journal of Physiology 2007; 579(1): 215-225.  [pubmed]  [online]  [pdf]

Smith TG, Brooks JT, Balanos GM, Lappin TR, Layton DM, Leedham DL, Liu C, Maxwell PH, McMullin MF, McNamara CJ, Percy MJ, Pugh CW, Ratcliffe PJ, Talbot NP, Treacy M and Robbins PA. Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS Medicine 2006; 3(7): 1178-1185.  [pubmed]  [online]  [pdf]


Reviews

Talbot NP, Smith TG and Dorrington KL. The mechanics and control of ventilation. Surgery 2011; 29: 212-216.  [online]  [pdf]

Nagel S, Talbot NP, Mecinović J, Smith TG, Buchan AM and Schofield CJ. Therapeutic manipulation of the HIF hydroxylases. Antioxidants and Redox Signaling 2010; 12(4): 481-501.  [pubmed]  [online]  [pdf]

Smith TG, Robbins PA and Ratcliffe PJ. The human side of hypoxia-inducible factor. British Journal of Haematology 2008; 141: 325-334.  [pubmed]  [online]  [pdf]


Editorial

Smith TG and Talbot NP. Prolyl hydroxylases and therapeutics. Antioxidants and Redox Signaling 2010; 12(4): 431-433.  [pubmed]  [online]  [pdf]

 
Book Chapter

Smith TG, Brooks JT, Balanos GM, Lappin TR, Layton DM, Leedham DL, Liu C, Maxwell PH, McMullin MF, McNamara CJ, Percy MJ, Pugh CW, Ratcliffe PJ, Talbot NP, Treacy M and Robbins PA. Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology. In: Integration in Respiratory Control – from Genes to Systems (Advances in Experimental Medicine and Biology Series). Eds: Poulin MJ and Wilson RJA. Springer Publishers, New York, 2008.  [pdf]


Correspondence

Talbot NP, Frise MC and Smith TG. Iron availability and outcomes in critical illness. Critical Care Medicine 2016; 44(10): e1011.  [pubmed [online [pdf]

Smith TG, Talbot NP, Dorrington KL and Robbins PA. Intravenous iron and pulmonary hypertension in intensive care. Intensive Care Medicine 2011; 37(10): 1720.  [pubmed [online [pdf]

Smith TG. Erythropoietin and HAPE. Aviation, Space and Environmental Medicine 2008; 79(8): 807.  [pubmed]  [pdf]

Smith TG and Robbins PA. Iron, pre-eclampsia and hypoxia-inducible factor. BJOG 2007; 114: 1581-1582.  [pubmed]  [online]  [pdf]

Pattinson KT, Sutherland AI, Smith TG, Dorrington KL and Wright AD. Acute mountain sickness, vitamin C, free radicals and HIF-1α. Wilderness and Environmental Medicine 2005; 16: 172-173.  [pubmed]  [pdf]


Published Abstracts

Middleton KE and Smith TG. Existing provision for emergency medical services at candidate sites for a UK spaceport. Aerospace Medicine and Human Performance 2017; 88(3): 291.  [pdf]

Turner BE, Hodkinson PD, Timperley AC and Smith TG. Effect of age on the pulmonary artery pressure response to simulated air travel. Aerospace Medicine and Human Performance 2015; 86(3): 245.  [pdf]

Brown LA, Prasad P, Smith TG and Johnston B. Pulmonary hypertension in airline passengers: a large case series from Oceania. Aerospace Medicine and Human Performance 2015; 86(3): 245.  [pdf]

Brown LA, Ho H, Smith TG, Windsor J and Phillips A. Feasibility of surgical percutaneous drain use in the microgravity environment. Aerospace Medicine and Human Performance 2015; 86(3): 162.  [pdf]

Smith TG. Mild hypoxia beyond the aircraft cabin. Aviation, Space and Environmental Medicine 2014; 85(3): 230.  [pdf]

Smith TG. Aviation hypoxia, cognition and human performance. Aviation, Space and Environmental Medicine 2013; 84(4): 425.  [pdf]

Smith TG, Talbot NP, Chang RW, Wilkinson E, Nickol AH, Newman DG, Robbins PA and Dorrington KL. Commercial air travel causes an increase in pulmonary artery pressure that can be clinically significant. Aviation, Space and Environmental Medicine 2013; 84(4): 377-378.  [pdf]

Smith TG. Recent advances in human pulmonary vascular physiology. Respiratory Investigation 2012; 75: EMS61.  [pdf]

Talbot NP, Bishop T, Nicholls LG, Smith TG, Dorrington KL, Buckler KJ, Robbins PA, Pugh CW and Ratcliffe PJ. A role for prolyl hydroxylase domain (PHD) proteins in respiratory control. American Journal of Respiratory and Critical Care Medicine 2011; 183: A6371.  [pdf]

Smith TG. Iron is an important factor in pulmonary physiology. Journal of the Intensive Care Society 2011; 12 (1): 57-58.  [pdf]

Formenti F, Beer P, Croft QP, Dorrington KL, Gale DP, Lappin TR, Lucas G, Maxwell PH, McMullin MF, O'Connor DF, Percy MJ, Smith TG, Talbot NP and Robbins PA. A 'gain-of-function' mutation in the hypoxia-inducible 2α gene does not reduce exercise capacity in humans. Journal of Physiological Sciences 2009; 59(Suppl. 1): 357.  [pdf]

Formenti F, Clarke K, Dorrington KL, Edwards L, Emmanuel Y, Lappin TR, McMullin MF, McNamara CJ, Mills W, Murphy JA, O'Connor DF, Percy MJ, Smith TG, Treacy M and Robbins PA. A genetic disease in humans demonstrates the importance of hypoxia-inducible factor in skeletal muscle metabolism. FASEB Journal 2009; 23: 955.32.  [pdf]

Smith TG, Bishop T, Carmeliet P, Dorrington KL, Maxwell PH, Pugh CW, Ratcliffe PJ and Robbins PA. The acute hypoxic ventilatory response is augmented in PHD2-deficient mice. American Journal of Respiratory and Critical Care Medicine 2008; 177: A270.  [pdf]

Smith TG, Croft QP, Dorrington KL and Robbins PA. Intravenous iron loading inhibits the pulmonary vascular response to hypoxia in humans. FASEB Journal 2007; 21: A1438.  [pdf]

Liu C, Balanos GM, Smith TG, Dorrington KL and Robbins PA. The effect of hydralazine on cardiorespiratory responses to hypoxia may not involve activation of the HIF pathway. FASEB Journal 2006; 20: LB30.  [pdf]

Smith TG, Ludbrook GL and van Renen G. Anaesthesia: a postoperative review. Anaesthesia and Intensive Care 1998; 26: 689.  [pdf]