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Prof Thomas G. Smith MBBS DAvMed DPhil (Oxon) FRCA FRCP FRAeS
Consultant Anaesthetist
Macintosh
Professor
Visiting
Professor of Aerospace Medicine
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SCIENTIFIC PUBLICATIONS
Pollock RD, Britton JK, Green ND, Hendriksen D, Hodkinson PD, Anderton RA and Smith TG. Prevention of G-induced effects on vision and consciousness during simulated suborbital spaceflight. Aerospace Medicine and Human Performance 2024 (in press) Miller-Smith M, Tucker N, Anderton R, Caplin N, Harridge SDR, Hodkinson PD, Narici MV, Pollock RD, Possnig C, Rittweger J, Smith TG and Di Giulio I. Lessons for flying astronauts with disabilities drawn from experience in aviation. Aerospace Medicine and Human Performance 2024: 95(9): 716-719. [pubmed] [online] [pdf] Talbot NP, Cheng H, Hanstock H, Smith TG, Dorrington KL and Robbins PA. Hypoxic pulmonary vasoconstriction does not limit maximal exercise capacity in healthy volunteers breathing 12% oxygen at sea level. Physiological Reports 2024;12(4): e15944. [pubmed] [online] [pdf] Brown LA, Griffiths JA, Santer P, Jakeman PM and Smith TG. Potential for using simulated altitude as a means of prehabilitation: a physiology study. Anaesthesia 2023; 78(12): 1472-1480. [pubmed] [online] [pdf] Connolly DM, Madden LA, Edwards VC, D’Oyly TJ, Harridge SD, Smith TG and Lee VM. Early human pathophysiological response to exertional hypobaric decompression stress. Aerospace Medicine and Human Performance 2023; 94(10): 738-749. [pubmed] [online] [pdf] Connolly DM, D’Oyly TJ, Harridge SDR, Smith TG and Lee VM. Decompression sickness risk in parachutist despatchers exposed repeatedly to high altitude. Aerospace Medicine and Human Performance 2023; 94(9): 666-677. [pubmed] [online] [pdf] Haddon A, Kanhai J, Nako O, Smith TG, Hodkinson PD and Pollock RD. Cardiorespiratory responses to voluntary hyperventilation during normobaric hypoxia. Aerospace Medicine and Human Performance 2023; 94(2): 59-65. [pubmed] [online] [pdf] Hearn E, Byford J, Wolfe C, Agyei C, Hodkinson PD, Pollock RD and Smith TG. Measuring arterial oxygen saturation using wearable devices under varying conditions. Aerospace Medicine and Human Performance 2023; 94(1): 42-47. [pubmed] [online] [pdf] Smith TG, Pollock RD, Britton JK, Green NDC, Hodkinson PD, Mitchell SJ, Stevenson AT. Physiological effects of centrifuge-simulated suborbital spaceflight. Aerospace Medicine and Human Performance 2022; 93(12): 830-839. [pubmed] [online] [pdf] Smith TG, Anastasescu I, Wight JM, Danaee A, Nair R and O'Brien TS. Perioperative management including dual cell salvage in a Jehovah’s Witness patient undergoing major urological surgery. Clinical Case Reports 2021; 9(11): e05098. [pubmed] [online] [pdf] Menden T, Alcaín GB, Stevenson AT, Pollock RD, Tank H, Hodkinson PD, Jolley CJ, Smith TG, Leonhardt S and Walter M. Dynamic lung behavior under high G acceleration monitored with electrical impedance tomography. Physiological Measurement 2021; 42: 094001 [pubmed] [online] [pdf] Pollock RD, Jolley CJ, Abid N, Couper JH, Estrada-Petrocelli L, Hodkinson PD, Leonhardt S, Magor-Elliott S, Menden T, Rafferty G, Richmond G, Robbins PA, Ritchie GAD, Segal MJ, Stevenson AT, Tank HD and Smith TG. Pulmonary effects of sustained periods of high-G acceleration relevant to suborbital spaceflight. Aerospace Medicine and Human Performance 2021; 92(8): 633-641. [pubmed] [online] [pdf] Smith TG, Ahmad I, Takhar A, Surda P and El-Boghdadly K. Unconventional multidisciplinary team strategy for tracheostomy in COVID-19. Anaesthesia Reports 2020; 8: 176-179. [pubmed] [online] [pdf] Talbot NP, Smith TG, Balanos GM, Dorrington KL, Maxwell PH and Robbins PA. Cardiopulmonary phenotype associated with human PHD2 mutation. Physiological Reports 2017; 5(7): e13224. [pubmed] [online] [pdf]
Smith TG, Formenti F, Hodkinson PD, Khpal M,
Mackenwells BP and Talbot NP. Monitoring tissue oxygen saturation in
microgravity on parabolic flights. Gravitational and Space Research
2016; 4(2): 2-7.
[online]
Talbot NP,
Smith TG, Lakhal-Littleton S, Gülsever C,
Rivera-Ch M, Dorrington KL, Mole DR and Robbins PA. Suppression of
plasma hepcidin by venesection during steady-state hypoxia. Blood 2016;
127(9): 1206-1207.
Bishop T,
Talbot NP, Turner PJ, Nicholls LG, Pascual A, Hodson EJ, Douglas G,
Fielding JW, Smith TG, Demetriades M,
Schofield CJ, Robbins PA, Pugh CW, Buckler KJ and Ratcliffe PJ. Carotid
body hyperplasia and enhanced ventilatory responses to hypoxia in mice
with heterozygous deficiency of PHD2. Journal of
Physiology 2013; 591(14): 3565-3577.
Smith TG, Talbot NP, Chang RW, Wilkinson E,
Nickol AH, Newman DG, Robbins PA and Dorrington KL. Pulmonary artery
pressure increases during commercial air travel in healthy passengers.
Aviation, Space and Environmental Medicine 2012; 83(7):
673-676.
Talbot NP,
Lakhal S, Smith TG, Privat C, Nickol AH, Rivera-Ch M, León-Velarde F,
Dorrington KL, Mole DR and Robbins PA. Regulation of hepcidin expression
at high altitude. Blood 2012; 119(3): 857-860.
Talbot NP,
Smith TG, Privat C, Nickol AH, Rivera-Ch,
M, León-Velarde F, Dorrington KL and Robbins PA. Intravenous iron
supplementation may protect against acute mountain sickness: a
randomized, double-blinded, placebo-controlled trial. High Altitude
Medicine and Biology 2011; 12(3): 265-269.
Formenti F,
Beer PA, Croft QP, Dorrington KL, Gale DP, Lappin TR, Lucas GS, Maher
ER, Maxwell PH, McMullin MF, O'Connor DF, Percy MJ, Pugh CW, Ratcliffe
PJ, Smith TG, Talbot NP and Robbins PA.
Cardiopulmonary function in two human disorders of
the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease
and HIF-2α
gain-of-function mutation.
FASEB Journal
2011;
25(6): 2001-2011.
Formenti F,
Constantin-Teodosiu D, Emmanuel Y, Cheeseman J, Dorrington KL, Edwards
LM, Humphreys SM, Lappin TR, McMullin MF, McNamara CJ, Mills W, Murphy
JA, O'Connor DF, Percy MJ, Ratcliffe PJ, Smith TG,
Treacy M, Frayn KN, Greenhaff PL, Karpe F, Clarke K
and Robbins PA.
Regulation of human metabolism by
hypoxia-inducible factor.
Proceedings of the National Academy of Sciences of the USA
2010; 107(28):
12722-12727.
Smith TG, Talbot NP, Privat C,
Rivera-Ch M, Nickol AH, Ratcliffe PJ, Dorrington KL,
León-Velarde F and Robbins PA.
Effects of iron supplementation and depletion on
hypoxic pulmonary hypertension: two randomized controlled trials.
Journal of the American Medical Association
2009; 302(13):
1444-1450.
Brooks JT, Elvidge GP, Glenny L, Gleadle JM, Liu
C, Ragoussis I,
Smith TG, Talbot NP, Winchester
L, Maxwell PH and Robbins PA.
Variations within oxygen-regulated gene expression
in humans.
Journal of Applied Physiology
2009; 106(1):
212-220.
Smith TG, Balanos GM, Croft QP,
Talbot NP,
Dorrington KL,
Ratcliffe PJ and Robbins PA.
The increase in pulmonary arterial pressure caused
by hypoxia depends on iron status.
Journal of Physiology
2008; 586(24):
5999-6005.
Liu C, Balanos GM, Fatemian M, Smith TG,
Dorrington KL and Robbins PA.
Effects of
hydralazine on the pulmonary vasculature and respiratory control in
humans.
Experimental Physiology
2008; 93(1):
104-114.
Liu C, Smith TG, Balanos GM,
Brooks JT, Crosby A, Herigstad M, Dorrington KL and Robbins PA. Lack of
involvement of the autonomic nervous system in early ventilatory and
pulmonary vascular acclimatization to hypoxia in humans.
Journal of
Physiology 2007; 579(1): 215-225.
Smith TG, Brooks JT, Balanos
GM, Lappin TR, Layton DM, Leedham DL, Liu C, Maxwell PH, McMullin MF,
McNamara CJ, Percy MJ, Pugh CW, Ratcliffe PJ, Talbot NP, Treacy M and
Robbins PA. Mutation of von Hippel-Lindau tumour suppressor and human
cardiopulmonary physiology.
PLoS
Medicine 2006; 3(7): 1178-1185.
Pollock RD, Hodkinson PD, and
Smith
TG. Oh G: The x, y and z of human
physiological responses to acceleration.
Experimental Physiology
2021; 106(12): 2367-2384.
Nagel S, Talbot NP, Mecinović J, Smith
TG, Buchan AM and Schofield CJ. Therapeutic manipulation of the
HIF hydroxylases.
Antioxidants
and Redox
Signaling
2010; 12(4): 481-501.
Hodkinson PD and Smith TG. Implications of the
hypobaric cabin environment during commercial air travel for passenger
fitness-to-fly. Thorax 2024: Aug 17:thorax-2024-221468.
Smith TG and Buckey JC.
Anaesthetists and aerospace medicine in a new era
of human spaceflight.
Anaesthesia
2022; 77(4): 384-388.
Smith TG and Talbot NP. Prolyl
hydroxylases and therapeutics.
Antioxidants
and Redox Signaling 2010;
12(4): 431-433. Smith TG. Cardiovascular physiology. In: Ernsting’s Aviation and Space Medicine. Eds: Gradwell D, Wilkinson E. CRC Press, London (6th edition): in press.
Smith TG and Talbot NP.
Aircraft cabin hypoxia and adverse medical events.
JAMA
2019; 321(20):
2030.
Smith TG, Talbot
NP, Dorrington KL and Robbins PA.
Intravenous iron and pulmonary hypertension in intensive care.
Intensive Care Medicine
2011; 37(10): 1720.
Smith TG. Erythropoietin and
HAPE.
Aviation, Space and Environmental Medicine
2008; 79(8): 807.
Smith TG and Robbins PA. Iron,
pre-eclampsia and hypoxia-inducible factor.
BJOG
2007; 114: 1581-1582.
Pattinson KT, Sutherland AI, Smith TG,
Dorrington KL and Wright AD.
Acute mountain sickness, vitamin C, free radicals
and HIF-1α. Wilderness and Environmental Medicine
2005; 16: 172-173.
Anderton RA, Pollock RD, Britton JK, Green NDC, Hendriksen D, Hodkinson
PD and Smith TG. Prevention of visual symptoms during
centrifuge-simulated suborbital spaceflight. Aerospace Medicine and
Human Performance 2024; 95(8): 517-518.
Miller M, Puisa V, Smith TG, Hodkinson PD and Vaquer S. Using a human
system failure model as an alternative approach to medical planning for
human space exploration medical systems. Aerospace Medicine and
Human Performance 2024; 95(8): 606.
Smith TG, Hearn E, Byford J, Wolfe C, Agyei C, Hodkinson PD and Pollock
RD. Measuring arterial oxygen saturation using wearable devices under
conditions relevant to the flight environment: a preliminary study. Aerospace Medicine and
Human Performance 2023; 94(4): 235.
Pollock RD, Coonjobeeharry M, Bychkov I, Maanum L, Coffey A, Bilger C,
Rafferty G, Jolley CJ, Hodkinson PD and Smith TG. Influence of
seat back angle and flight jacket wear on work of breathing. Aerospace Medicine and
Human Performance 2023; 94(4): 191-192.
Di Giulio I, Anderton RA, Harridge S, Hodkinson PD, Narici M, Pollock RD, Rittweger J, Smith TG
and Miller-Smith M. Investigating the
potential for parastronauts: support for the ESA parastronaut project.
Aerospace Medicine and
Human Performance 2023; 94(4): 309.
Lee VM,
Connolly DM, D'Oyly TD and Smith TG. Decompression sickness risk
associated with repeat altitude exposure. Aerospace Medicine and
Human Performance 2023; 94(4): 161.
Smith TG, Pollock RD, Britton J, Green NDC, Hodkinson PD, Mitchell SJ
and Stevenson AT. Physiological effects of centrifuge-simulated
suborbital spaceflight. Aerospace Medicine and
Human Performance 2022; 93(3): 155.
Stevenson AT, Pollock RD, Tank HD, Magor-Elliott S, Couper JH, Richmond
G, Abid N, Hodkinson PD, Ritchie GA, Robbins PA and Smith TG. Impairment
of gas exchange in the lung during sustained +Gx acceleration relevant
to suborbital spaceflight profiles. Aerospace Medicine and
Human Performance 2019; 90(3): 294.
Pollock RD, Stevenson AT, Jolley CJ, Rafferty GF, Estrada L, Segal MJ,
Tank HD, Menden T, Leonhardt S and Smith TG. Ventilation, respiratory
drive and breathing mechanics during sustained +Gx acceleration relevant
to suborbital spaceflight profiles. Aerospace Medicine and
Human Performance 2019; 90(3): 295.
Talbot NP, Cheng H, Smith TG, Dorrington KL
and Robbins PA. Effects of intravenous iron on hypoxic pulmonary
vasoconstriction and maximal exercise capacity during sustained (8 h)
hypoxia in healthy volunteers. European Respiratory Journal
2018 52: Suppl. 62, PA2477.
Russomano T, Gradwell D, Smith TG and Harridge S.
Aerospace physiology and medicine at King’s College London.
Aerospace Medicine and Human Performance 2018; 89(3): 224-225.
Turner BE, Hodkinson PD, Timperley AC and Smith TG.
Effect of age on the pulmonary artery pressure response to simulated air
travel. Aerospace Medicine and Human Performance 2015; 86(3):
245.
Smith TG. Aviation hypoxia, cognition and
human performance.
Aviation, Space and Environmental Medicine 2013; 84(4):
425.
Smith TG, Talbot NP, Chang RW, Wilkinson E,
Nickol AH, Newman DG, Robbins PA and Dorrington KL. Commercial air
travel causes an increase in pulmonary artery pressure that can be
clinically significant.
Aviation, Space and Environmental Medicine 2013; 84(4):
377-378.
Smith TG. Recent advances in human
pulmonary vascular physiology. Respiratory Investigation 2012;
75: EMS61.
Talbot NP,
Bishop T, Nicholls LG, Smith TG, Dorrington
KL, Buckler KJ, Robbins PA, Pugh CW and Ratcliffe PJ. A role for prolyl
hydroxylase domain (PHD) proteins in respiratory control. American
Journal of Respiratory and Critical Care Medicine 2011; 183: A6371.
Smith TG. Iron is
an important factor in pulmonary physiology.
Journal of the Intensive Care Society
2011; 12 (1): 57-58.
Formenti F,
Beer P, Croft QP, Dorrington KL, Gale DP, Lappin TR, Lucas G, Maxwell
PH, McMullin MF,
O'Connor DF, Percy MJ, Smith TG,
Talbot NP and Robbins PA. A 'gain-of-function' mutation in the
hypoxia-inducible 2α
gene does not reduce exercise capacity in humans. Journal of
Physiological Sciences 2009; 59(Suppl. 1): 357.
Formenti F,
Clarke K, Dorrington KL, Edwards L, Emmanuel Y, Lappin TR, McMullin MF,
McNamara CJ, Mills W, Murphy JA, O'Connor DF, Percy MJ, Smith TG,
Treacy M and Robbins PA. A genetic disease in humans demonstrates the
importance of hypoxia-inducible factor in skeletal muscle metabolism.
FASEB Journal 2009; 23: 955.32.
Smith TG, Bishop T, Carmeliet
P, Dorrington KL, Maxwell PH, Pugh CW, Ratcliffe PJ and Robbins PA. The
acute hypoxic ventilatory response is augmented in PHD2-deficient mice.
American Journal of Respiratory and Critical Care Medicine
2008; 177: A270.
Smith TG, Croft QP, Dorrington
KL and Robbins PA. Intravenous iron loading inhibits the pulmonary
vascular response to hypoxia in humans.
FASEB Journal
2007; 21: A1438.
Liu C, Balanos GM, Smith TG,
Dorrington KL and Robbins PA.
The effect of hydralazine on cardiorespiratory responses to hypoxia may
not involve activation of the HIF pathway.
FASEB Journal
2006; 20: LB30.
Smith TG, Ludbrook GL and van
Renen G. Anaesthesia: a postoperative review.
Anaesthesia
and Intensive Care 1998; 26: 689.
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